Table 4.

Change in median ELISPOT count across all subjects, for each peptide pool, following immunization.

	post 1st immunisation			post 2nd immunisation			post 3rd immunisation
Peptide pool	% changea	No. of Subjects negative	No. of Subjects positiveb	% changea	No. of Subjects negative	No. of Subjects positiveb	% changea	No. of Subjects negative	No. of Subjects positiveb
1–5	−43	15	5	−9	11	9	−44	16	4
6–10	−27	13	7	31	12	8	−50	14	6
11–15	0	11	9	−3	8	12	−37	13	7
16–20	0	9	10	1	7	12	−22	11	7
21–25	107	3	17	9	11	9	25	8	12
26–30	53	5	13	31	10	10	42	8	12
31–35	−29	11	9	−16	11	9	−32	14	6
36–40	72	5	15	−15	12	7	−24	8	12
41–45	−31	10	9	−32	14	6	−40	11	9
46–50	−40	14	6	3	9	11	−57	16	4
51–55	−31	12	8	−25	13	7	−49	14	6

^a% change in median spot count for this peptide pool from the pre-immunisation median.

^ba positive subject showed a spot count more than 2 SD above the mean spot count for that subject compared to pre-immunisation.