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Histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity in lung tissue from idiopathic pulmonary arterial hypertension (IPAH) and controls. Nuclear extracts were prepared from whole lung tissue from IPAH (n = 10) and controls (n = 10) and HDAC (A) and HAT (B) activity and their ratio were determined (C). *P < 0.05, **P < 0.01.
