Table 3.
HAI antibody responses.
| A(H1N1) |
A(H3N2) |
B Victoria |
B Yamagata |
||||||
|---|---|---|---|---|---|---|---|---|---|
| IIV4 | IIV3 | IIV4 | IIV3 | IIV4 | IIV3 | IIV4 | IIV3 | ||
| Measure | Assessment | N = 863 | N = 344 | N = 863 | N = 344 | N = 863 | N = 176 | N = 862 | N = 168 |
| GMT (95% CI) | Day 0 | 142 (125, 161) | 149 (122, 183)a | 209 (182, 240) | 229 (185, 284)a | 61.6 (54.3, 69.8) | 62.8 (47.7, 82.7)b | 46.3 (40.9, 52.4) | 39.8 (30.1, 52.7)c |
| 28 d post-vaccinationf | 971 (896, 1052) | 1141 (1006, 1295)a | 1568 (1451, 1695) | 1746 (1551, 1964)a | 1050 (956, 1154) | 1120 (921, 1361)b | 1173 (1078, 1276) | 1211 (1003, 1462)c | |
| GMTR vs. day 0 (95% CI) | 28 d post-vaccinationf | 6.86 (6.24, 7.53) | 7.65 (6.54, 8.95)a | 7.49 (6.72, 8.35) | 7.61 (6.39, 9.05)a | 17.1 (15.5, 18.8) | 17.8 (14.5, 22.0)b | 25.3 (22.8, 28.2) | 30.4 (23.8, 38.9)c |
| Seroprotection, % (95% CI)d | Day 0 | 76.4 (73.4, 79.2) | 77.3 (72.5, 81.6)a | 78.1 (75.2, 80.8) | 79.4 (74.7, 83.5)a | 60.8 (57.5, 64.1) | 65.9 (58.4, 72.9)b | 51.7 (48.3, 55.1) | 47.0 (39.3, 54.9)c |
| 28 d post-vaccinationf | 98.7 (97.7, 99.4) | 98.8 (97.0, 99.7)a | 99.8 (99.2, 100.0) | 100.0 (98.9, 100.0)a | 98.7 (97.7, 99.4) | 99.4 (96.9, 100.0)b | 99.4 (98.7, 99.8) | 98.8 (95.8, 99.9)c | |
| Seroconversion or significant increase in titer, % (95% CI)e | 28 d post-vaccinationf | 65.7 (62.4, 68.9) | 65.7 (60.4, 70.7)a | 64.8 (61.5, 68.0) | 67.7 (62.5, 72.6)a | 84.8 (82.3, 87.2) | 90.3 (85.0, 94.3)b | 88.5 (86.2, 90.6) | 89.9 (84.3, 94.0)c |
Values are for the other immunogenicity analysis set. Day 0 values were before vaccination, day 28/56 values were 28 d after the last vaccine dose. CI, confidence interval; GMT, geometric mean titer; GMTR, geometric mean titer ratio.
a
Pooled IIV3s.
b
IIV3-1, which contained the B Victoria lineage (B/Brisbane).
c
IIV3-2, which contained the B Yamagata lineage (B/Massachusetts).
d
Haemagglutination inhibition (HAI) titer ≥ 40.
e
Pre-vaccination HAI titer < 10 to a post-vaccination HAI titer ≥ 40 or with a pre-vaccination HAI titer ≥ 10 and ≥ 4-fold increase in HAI titer.
f
Day 28 for subjects vaccinated with one dose, day 56 for subjects vaccinated with 2 doses.