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. 2017 Jan 4;13(1):e1006096. doi: 10.1371/journal.ppat.1006096

Table 2. RNA-sequencing analysis for Af293 and ΔatrR in response to azole drugs.

RPKM
Af293 ΔatrR
ID Gene name +DMSO +FLCZ +MCZ +DMSO +FLCZ +MCZ ΔatrR (DMSO) /Af293 (DMSO) Af293 (FLCZ) /Af293 (DMSO) Af293 (MCZ) /Af293 (DMSO) Predicted function
AtrR- and azole treatment-dependent genes
Afu4g06890 cyp51A 249.0 901.5 952.8 3.9 15.3 18.9 0.02 3.62 3.83 14-alpha sterol demethylase
Afu1g03150 erg24A 45.6 605.5 736.4 2.0 16.7 35.7 0.04 13.28 16.15 C-14 sterol reductase
Afu1g05720 erg24B 95.0 441.6 409.8 26.2 23.6 32.1 0.28 4.65 4.31 C-14 sterol reductase
Afu8g02440 erg25A 597.8 1965.1 1906.6 10.0 13.0 24.7 0.02 3.29 3.19 C-4 methyl sterol oxidase
Afu3g00810 hyd1 62.94 320.39 402.68 0.00 19.36 20.35 0.00 5.09 6.40 cholestenol delta-isomerase, putative
Afu3g00820 15.96 123.97 118.89 3.63 2.10 13.82 0.23 7.77 7.45 putative exported protein
PDR sub-family ABC transporters
Afu1g14330 cdr1B 61.1 125.5 111.3 5.7 9.9 6.9 0.09 2.06 1.82 ABC transporter, putative
Afu1g17440 abcA 0.3 0.0 0.0 0.3 0.0 0.4 1.06 0.00 0.00 ABC drug exporter AbcA
Afu2g15130 24.0 36.1 28.4 24.8 22.2 14.9 1.03 1.50 1.18 ABC multidrug transporter, putative
Afu3g01400 10.6 26.7 10.1 27.6 112.7 59.7 2.59 2.51 0.95 ABC multidrug transporter, putative
Afu3g07300 atrI 9.7 11.0 11.1 18.5 20.2 18.7 1.91 1.14 1.15 ABC multidrug transporter, putative
Afu4g01050 0.4 3.1 0.0 0.4 5.2 3.8 1.06 8.79 0.00 ABC multidrug transporter, putative
Afu5g00790 2.6 11.3 10.1 6.8 17.8 60.1 2.65 4.39 3.91 ABC multidrug transporter, putative
Afu5g02260 5.2 5.3 2.7 4.1 6.0 3.1 0.80 1.03 0.52 ABC multidrug transporter, putative
Afu5g09460 29.4 20.7 18.6 37.6 23.6 24.8 1.28 0.70 0.63 ABC transporter, putative
Afu6g04360 atrF 3.4 3.7 1.9 8.5 6.8 3.0 2.51 1.10 0.57 ABC drug exporter AtrF
Afu6g08020 8.1 9.2 8.1 7.6 13.8 7.2 0.94 1.14 1.00 ABC transporter, putative
Afu8g02650 3.3 5.4 6.8 5.2 5.1 5.9 1.59 1.65 2.09 ABC multidrug transporter, putative
Transcription factors
Afu5g09420 ccg-8 46.4 40.8 43.6 41.4 41.1 47.2 0.89 0.88 0.94 clock controled protein (Ccg-8), putative
Afu1g16460 ads-4 88.0 103.1 94.8 83.4 129.5 135.8 0.95 1.17 1.08 bZIP transcription factor (LziP), putative
Members of SREBP pathway
Afu2g01260 srbA 59.0 95.3 80.5 37.7 27.0 30.8 0.64 1.62 1.37 HLH transcription factor, putative
Afu1g12080 dscA 23.0 18.8 16.0 21.9 26.2 14.3 0.95 0.82 0.70 RING finger ubiquitin ligase (Tul1), putative
Afu4g11680 dscB 70.6 60.4 65.5 28.3 43.5 53.3 0.40 0.85 0.93 conserved hypothetical protein
Afu4g10700 dscC 44.4 55.5 41.5 29.2 45.2 48.2 0.66 1.25 0.94 conserved membrane protein, putative
Afu3g08340 dscD 10.0 12.6 6.0 15.2 23.7 10.4 1.52 1.26 0.60 conserved hypothetical protein
Afu1g14320 dscE 47.9 61.7 75.9 52.8 56.9 59.2 1.10 1.29 1.58 UBX domain protein
Afu6g12750 rbdB(rbdA) 55.6 45.8 48.9 35.0 43.3 21.1 0.63 0.82 0.88 rhomboid family protein, putative
Afu6g02150 sppA 28.6 36.4 26.7 27.2 16.7 21.9 0.95 1.27 0.93 signal peptide peptidase, putative