Figure 4.

Treatment response rates in patients with baseline abdominal pain scores ≥1.36 using a composite endpoint. Composite treatment response defined as ≥30% improvement in abdominal pain and ≥1 increase in spontaneous bowel movements per week vs. baseline for ≥6 of 12 treatment weeks by baseline abdominal pain score (pooled data). *P < 0.01. ^† P < 0.05. ^‡Equivalent to 3 on a scale of 0–10. ^§Scale from 0 (absent) to 4 (very severe). P values compare placebo vs. lubiprostone, based on the Cochran–Mantel–Haenszel test stratified by pooled site.