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. 2016 Nov 23;80(6):909–923. doi: 10.1002/ana.24815

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© 2016 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Cyclic adenosine monophosphate (cAMP) levels are decreased in vulnerable brain regions of Cln3^Δex7/8 mice. Cln3^Δex7/8 and wild‐type (WT) mice (n = 5–10/group) were sacrificed at 7 (top panel) or 12 months of age (bottom panel), whereupon cAMP levels were quantified in the thalamus (TH), hippocampus (HPC), visual cortex (VC), and somatosensory barrel field cortex (S1BF) by enzyme‐linked immunosorbent assay and normalized to total protein to account for differences in tissue size. Results are combined from 2 independent experiments, and significant differences between WT and Cln3^Δex7/8 mice are denoted by asterisks (p < 0.05).