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PF‐06266047 restores cyclic adenosine monophosphate (cAMP) levels in Cln3Δex7/8 mice. Cln3Δex7/8 and wild‐type (WT) mice received PF‐06266047 (PF; 0.5mg/kg) or vehicle via daily oral gavage beginning at 1 month of age, whereupon animals were sacrificed 6 months later for cAMP quantitation by immunofluorescence staining in the thalamus, visual cortex, and hippocampus (n = 5/group). Significant differences between groups are denoted by asterisks (***p < 0.001; ****p < 0.0001).
