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. 2016 Nov 23;80(6):909–923. doi: 10.1002/ana.24815

Figure 5.

Figure 5

Phosphodiesterase 4 inhibitors reduce astrocyte activation in Cln3Δex7/8 mice. Cln3Δex7/8 and wild‐type (WT) mice (n = 4–8/group) received vehicle, (A, B) 5mg/kg roflumilast (RF), or (C, D) 0.5mg/kg PF‐06266047 (PF) via daily oral gavage beginning at 1 month of age, whereupon animals were sacrificed 6 months later for quantitative assessments of astrocyte activation in the somatosensory barrel field cortex (S1BF) and thalamus by immunofluorescence staining for glial fibrillary acidic protein (GFAP). Significant differences between groups are denoted by asterisks (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001).