Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Nov 23;80(6):909–923. doi: 10.1002/ana.24815

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2016 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Phosphodiesterase 4 inhibitors attenuate lysosomal pathology in the Cln3^Δex7/8 brain. Cln3^Δex7/8 and wild‐type (WT) mice (n = 4–8/group) received vehicle, (A, B) 5mg/kg roflumilast (RF), or (C, D) 0.5mg/kg PF‐06266047 (PF) via daily oral gavage beginning at 1 month of age, whereupon animals were sacrificed 6 months later for quantitative assessments of lysosomal‐associated membrane protein 1 (LAMP‐1) expression in the somatosensory barrel field cortex (S1BF) and thalamus. Significant differences between groups are denoted by asterisks (**p < 0.01; ****p < 0.0001).