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. 2016 Jun 21;57(1):7–32. doi: 10.1002/jcph.766

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© 2016, The Authors. The Journal of Clinical Pharmacology Published by Wiley Periodicals, Inc. on behalf of American College of Clinical Pharmacology

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Evolution of therapeutic monoclonal antibodies. Fully mouse antibodies developed with early hybridoma technology were highly immunogenic. Development of recombinant DNA technologies resulted in more humanized and less immunogenic antibodies: chimeric, humanized, and fully human.45, 46, 48