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. 2016 Dec 22;2016:5959721. doi: 10.1155/2016/5959721

Figure 1.

Figure 1

pRB blocks cell cycle progression by repressing the E2F-target gene transcription through the recruitment of transcriptional corepressors and/or chromatin remodeling protein factors, such as HDAC, Sin3, CtBP, and SWI/SNF, at promoter regions.