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A. Control cells, IDH1 wild type stable cells, IDH1 R132H mutant stable cells were treated without or with 5-FU for one day. Cleaved caspase 3 was used to detect level of apoptosis. B. Ratio of cleaved caspase 3 to caspase 3 was quantified. (Control + 5FU) vs. (IDH1 R132H ox + 5FU) (p<0.05).
