Table 1.

The Weekly Schedule of the CMS Protocol

	Daytime	Evening
Monday	Intermittent illumination	No stress
Tuesday	Water deprivation	Cage tilting
Wednesday	Strobe flashing	Wetting
Thursday	No stress	Food and water deprivation
Friday	Sucrose test	Grouping
Saturday	Food and water deprivation	Cage tilting
Sunday	Cage tilting	Wetting

Every micro‐stressor lasted for 10‐14 hours.

Intermittent illumination: light on/off every 2 h; Cage tilting into a 45° position; Strobe flashing: stroboscopic lightning; Wetting: pouring water into the cage to damp bedding; Grouping: pairing two rats by having an unfamiliar partner at each grouping session.