TABLE 1.
Baseline characteristics of the kidney transplant cohort at one-month post-transplantation
| Characteristic | N=143 |
|---|---|
| Age at transplant (years) | 49 (40, 58) |
|
| |
| Race | |
| White | 107 (75%) |
| Black | 33 (23%) |
| Other | 3 (2%) |
|
| |
| Sex (male) | 105 (73%) |
|
| |
| BMI | 27.1 (23.3, 30.5) |
|
| |
| Tobacco use | |
| Never | 75 (53%) |
| Current | 12 (8%) |
| Former | 56 (39%) |
|
| |
| Pack Years | 10 (3, 25) |
|
| |
| Cardiovascular disease1 | 55 (39%) |
|
| |
| Diabetes | 54 (38%) |
|
| |
| Hypertension | 136 (95%) |
|
| |
| Hyperlipidemia | 81 (57%) |
|
| |
| Months on Dialysis pre-transplant | 26.4 (13.5, 51.3) |
|
| |
| Primary cause of end-stage renal disease | |
| Diabetic nephropathy | 42 (29%) |
| Hypertensive nephropathy | 32 (22%) |
| Glomerular Disease | 30 (21%) |
| Tubulintersitial Disease | 8 (6%) |
| Cystic Disease | 19 (13%) |
| Structure Disease | 1 (1%) |
| Renal Neoplasia | 1 (1%) |
| Other | 10 (7%) |
|
| |
| Estimated Glomerular Filtration Rate (ml/min/m2) | 57 (48, 69) |
|
| |
| Mean Arterial Pressure (mm Hg) | 95.6 (87.5, 103.8) |
|
| |
| Induction Immunosuppression | |
| Alemtuzumab | 129 (90%) |
| Basiliximab | 13 (9%) |
| Anti-Thymocyte Globulin | 1 (1%) |
|
| |
| Maintenance Immunosuppression | |
| Tacrolimus | 140 (98%) |
| Everolimus | 4 (3%) |
| Sirolimus | 0 (0%) |
| Mycophenolate | 137 (96%) |
| Prednisone | 80 (56%) |
|
| |
| Anti-Hypertensive Medication | |
| ACE2 Inhibitors | 4 (3%) |
| Beta Blockers | 82 (57%) |
| Angiotensin Receptor Blocker | 4 (3%) |
|
| |
| Statin Therapy | 27 (19%) |
|
| |
| Slow Graft Function3 | 21 (15%) |
|
| |
| Delayed Graft Function | 9 (6%) |
Values expressed as median (25th, 75th percentiles), number (percent), or mean (standard deviation).
1
Cardiovascular disease includes coronary artery disease, myocardial infarction, coronary artery bypass grafting, percutaneous coronary intervention, congestive heart failure, arrhythmia, stroke, and peripheral vascular disease.
2
Angiotensin Converting Enzyme
3
Slow graft function was defined as a less than a 50% drop in serum creatinine over 72 hours after transplant without the need for hemodialysis.