Table 1.
Baseline demographics by donor kidney subtype and treatment
| Characteristic | Belatacept MI | Belatacept LI | CsA |
|---|---|---|---|
| Age, years, mean (SD) | |||
| UNOS ECD | 59.1 (11.36) | 58.9 (10.97) | 58.9 (10.74) |
| DCD | 56.7 (13.35) | 53.7 (14.33) | 49.9 (11.92) |
| Anticipated CIT ≥24 h | 49.1 (13.27) | 48.2 (12.42) | 47.0 (12.30) |
| Male, n/n (%) | |||
| UNOS ECD | 85/126 (67.5) | 87/119 (73.1) | 78/129 (60.5) |
| DCD | 13/18 (72.2) | 14/19 (73.7) | 11/18 (61.1) |
| Anticipated CIT ≥24 h | 21/40 (52.5) | 28/37 (75.7) | 27/37 (73.0) |
| Region, n/n (%) | |||
| North America | |||
| UNOS ECD | 33/126 (26.2) | 24/119 (20.2) | 32/129 (24.8) |
| DCD | 8/18 (44.4) | 10/19 (52.6) | 7/18 (38.9) |
| Anticipated CIT ≥24 h | 9/40 (22.5) | 7/37 (18.9) | 7/37 (18.9) |
| South America | |||
| UNOS ECD | 23/126 (18.3) | 23/119 (19.3) | 25/129 (19.4) |
| DCD | 1/18 (5.6) | 3/19 (15.8) | 1/18 (5.6) |
| Anticipated CIT ≥24 h | 21/40 (52.5) | 21/37 (56.8) | 24/37 (64.9) |
| Europe | |||
| UNOS ECD | 69/126 (54.8) | 71/119 (59.7) | 72/129 (55.8) |
| DCD | 9/18 (50.0) | 6/19 (31.6) | 10/18 (55.6) |
| Anticipated CIT ≥24 h | 10/40 (25.0) | 8/37 (21.6) | 6/37 (16.2) |
| CIT, h, mean (median, range) | |||
| UNOS ECD | 16.9 (16.6, 0.7–32.8) | 19.0 (18.6, 5.8–42.7) | 17.1 (16.8, 4.5–36.8) |
| DCD | 17.4 (15.3, 4.3–38.0) | 21.2 (21.0, 7.8–43.0) | 18.4 (18.0, 6.0–29.9) |
| Anticipated CIT ≥24 h | 29.5 (29.1, 0.0–43.3) | 27.9 (27.8, 12.3–44.2) | 27.9 (26.3, 15.1–42.7) |
| Pretransplant dialysis, n/n (%) | |||
| UNOS ECD | 118/126 (93.7) | 112/119 (94.1) | 119/129 (92.2) |
| DCD | 15/18 (83.3) | 16/19 (84.2) | 17/18 (94.4) |
| Anticipated CIT ≥24 h | 39/40 (97.5) | 37/37 (100.0) | 34/37 (91.9) |
| Pretransplant diabetes, n/n (%) | |||
| UNOS ECD | 28/126 (22.2) | 23/119 (19.3) | 36/129 (27.9) |
| DCD | 4/18 (22.2) | 2/19 (10.5) | 11/18 (61.1) |
| Anticipated CIT ≥24 h | 6/40 (15.0) | 3/37 (8.1) | 6/37 (16.2) |
| Categorized PRA,a n/n (%) | |||
| <20% | |||
| UNOS ECD | 123/126 (97.6) | 113/119 (95.0) | 118/129 (91.5) |
| DCD | 17/18 (94.4) | 15/19 (78.9) | 17/18 (94.4) |
| Anticipated CIT ≥24 h | 37/40 (92.5) | 37/37 (100.0) | 33/37 (89.2) |
| ≥20% | |||
| UNOS ECD | 0/126 (0) | 0/119 (0) | 4/129 (3.1) |
| DCD | 0/18 (0) | 1/19 (5.3) | 0/18 (0) |
| Anticipated CIT ≥24 h | 0/40 (0) | 0/37 (0) | 2/37 (5.4) |
CIT, cold ischemia time; CsA, cyclosporine; DCD, donation after cardiac death; ECD, expanded criteria donor; LI, less intensive; MI, more intensive; PRA, panel reactive antibody; SD, standard deviation; UNOS, United Network for Organ Sharing.
a
PRA data missing for the remaining patients.