Table 3.
Comparative risk of developing drug related side effects with angiotensin converting enzyme inhibitors or angiotensin II receptor antagonists
|
Angiotensin converting enzyme inhibitor v placebo or no treatment (36 trials)
|
Angiotensin II receptor antagonist v placebo or no treatment (4 trials)
|
|||||
|---|---|---|---|---|---|---|
| Side effect | No of trials reporting outcome | No of patients | Relative risk (95% CI)* | No of trials reporting outcome | No of patients | Relative risk (95% CI)* |
| Cough | 10 | 2269 | 2.74 (1.74 to 4.30) | 1 | 91 | 1.87 (0.22 to 16.01) |
| Headache | 3 | 1326 | 0.97 (0.17 to 5.71) | 1 | 91 | 0.47 (0.03 to 7.22) |
| Hyperkalaemia | 2 | 1271 | 0.85 (0.35 to 2.08) | 1 | 1148 | 5.41 (1.20 to 24.28) |
| Impotence | 6 | 1569 | 1.26 (0.68 to 2.34) | — | — | — |
*
Values <1 favour intervention, values >1 favour placebo or no treatment.