Table 1.
Description of cases and controls
| Matching factors | Cases (N = 144 959) | Controls (N = 549 336) |
|---|---|---|
| Ever prescribed a statin | ||
| Yes | 32 119 (22·2) | 111 023 (20·2) |
| No | 112 840 (77·8) | 438 313 (79·8) |
| Sex | ||
| Male | 58 888 (40·6) | 214 064 (39·0) |
| Female | 86 071 (59·4) | 335 272 (61·0) |
| Age | ||
| 18–29 | 10 849 (7·48) | 38 761 (7·06) |
| 30–49 | 28 762 (19·84) | 104 708 (19·06) |
| 50–59 | 27 833 (19·2) | 105 157 (19·1) |
| 60–69 | 31 134 (21·5) | 121 108 (22·0) |
| 70–79 | 28 025 (19·3) | 110 097 (20·0) |
| 80–89 | 15 891 (11·0) | 61 566 (11·2) |
| ≥ 90 | 2465 (1·7) | 7939 (1·4) |
| Socioeconomic status (practice level) | ||
| 1 | 28 938 (20·0) | 109 663 (20·0) |
| 2 | 28 853 (19·9) | 109 253 (19·9) |
| 3 | 29 811 (20·6) | 112 888 (20·5) |
| 4 | 30 550 (21·1) | 115 678 (21·1) |
| 5 | 26 807 (18·5) | 101 854 (18·5) |
| Other characteristics | ||
| Mean (IQR) length of follow‐up, years | 8·6 (4·3–12·1) | 8·6 (4·3–12·1) |
| Body mass index category | ||
| Underweight | 2776 (1·9) | 10 549 (1·9) |
| Normal weight | 50 530 (34·9) | 188 060 (34·2) |
| Overweight | 47 886 (33·0) | 177 603 (32·3) |
| Obese | 29 581 (20·4) | 109 440 (19·9) |
| Missing | 14 186 (9·8) | 63 684 (11·6) |
| Smoking status | ||
| Nonsmoker | 54 751 (37·8) | 208 436 (37·9) |
| Current smoker | 36 107 (24·9) | 141826 (25·8) |
| Former smoker | 52 353 (36·1) | 186 373 (33·9) |
| Missing | 1784 (1·2) | 12 701 (2·3) |
| Alcohol use | ||
| Nondrinker | 14 481 (10·0) | 56 774 (10·3) |
| Current drinker | 103 113 (71·1) | 383 976 (69·9) |
| Former drinker | 12 786 (8·8) | 45 242 (8·2) |
| Missing | 14 579 (10·1) | 63 344 (11·5) |
| Cardiovascular disease | 15 855 (10·94) | 53 352 (9·71) |
| HIV | 128 (0·09) | 97 (0·02) |
| Lymphoma | 444 (0·31) | 386 (0·07) |
| Leukaemia | 205 (0·14) | 368 (0·07) |
| Myeloma | 492 (0·34) | 816 (0·15) |
| Haematopoietic stem cell transplantation | 26 (0·02) | 3 (0·00) |
| Other unspecified cellular immune deficiencies | 95 (0·07) | 190 (0·03) |
| Other immunosuppressive therapy | 2164 (1·49) | 3822 (0·70) |
| Oral corticosteroids | 502 (0·35) | 1058 (0·19) |
| Rheumatoid arthritis | 3111 (2·15) | 8029 (1·46) |
| Systemic lupus erythematosus | 387 (0·27) | 818 (0·15) |
| Inflammatory bowel disease | 1851 (1·28) | 5118 (0·93) |
| COPD | 6815 (4·70) | 20 201 (3·68) |
| Asthma | 10 243 (7·07) | 31 865 (5·80) |
| Chronic kidney disease | 8724 (6·02) | 29 437 (5·36) |
| Depression | 6830 (4·71) | 22 052 (4·01) |
| Diabetes | 11 430 (7·88) | 41 320 (7·52) |
| Type 1 | 396 (0·27) | 1054 (0·19) |
| Type 2 | 10 359 (7·15) | 38 136 (6·94) |
| Unknown | 675 (0·47) | 2130 (0·39) |
| Missing data in any variable | 20 598 (14·2) | 88 233 (16·1) |
IQR, interquartile range; COPD, chronic obstructive pulmonary disease. Values are n (%) unless otherwise stated.