Table 2.
Superovulation variables, serum hCG, oocytes and embryo parameters, CPRs and LBRs in relation to BMI categories and u-hCG dosages
| Variable | BMI | |||
|---|---|---|---|---|
| <25 (n=136) | ≥25 - <30 (n=84) | ≥30 (n=75) | P value | |
| Dose of HCG administered | 10547.9 ± 3169.0 | 10333.3 ± 2784.4 | 10166.7 ± 2849.2 | 0.623 |
| Serum hCG (IU) 12-14 hours after hCG trigger | 312.7 ± 16.5a | 230.4 ± 12.0b | 162.8 ± 9.6c | 0.001 |
| Gn stimulation (days) | 10.2 ± 0.2 | 10.6 ± 0.2 | 10.2 ± 0.2 | NS |
| Total Gn dose (IU) | 4454.0 ± 286.5 | 5342.9 ± 404.9.5 | 4592.9 ± 415.5 | NS |
| Total follicles developed | 19.7 ± 0.9b | 19.4 ± 1.1b | 22.5 ± 1.1a | 0.029 |
| Follicles ≥14 mm day of hCG | 10.9 ± 0.4b | 10.6 ± 0.6b | 12.2 ± 0.6a | 0.049 |
| E2 day of hCG (pg/mL) | 2508.7 ± 84.1 | 2396.3 ± 194.2 | 2363.5 ± 107.8 | NS |
| Endometrium thickness on day of hCG (mm) | 10.2 ± 0.2 | 10.6 ± 0.2 | 10.7 ± 0.3 | NS |
| Oocytes collected | 13.7 ± 0.7 | 13.9 ± 1.1 | 15.4 ± 0.9 | NS |
| Mature oocytes | 10.9 ± 0.6 | 11.4 ± 0.8 | 12.0 ± 0.7 | NS |
| Oocytes fertilized | 8.4 ± 0.5 | 9.2 ± 0.7 | 9.3 ± 0.6 | NS |
| Embryos transferred | 2.6 ± 0.1 | 2.5 ± 0.1 | 2.8 ± 0.1 | NS |
| CPR (%) | 61/136 (44.9) | 35/84 (41.7) | 28/75 (37.3) | NS |
| LBR (%), n=292* | 54/136 (39.7) | 30/81 (37.0) | 24/75 (32.0) | NS |
Except otherwise stated results are means ± SE from two-way ANOVAs with Tukey post hoc analysis as appropriate. No interactions were detected between BMI and hCG. Different letters denote differences among groups (a vs. b, a vs.c, and b vs. c; P<0.05). BMI; Body mass index, u-hCG; Urinary derived human chorionic gonadotropin, Gn; Gonadotropin, E2; Estradiol, CPR; Clinical pregnancy rate, LBR; Live birth rate, NS; Nonsignificant, and *; 3 cycles were lost to follow up hence the outcome of pregnancy in these 3 cases was not known.