Table 3.
Superovulation variables, serum hCG, oocytes and embryo parameters, CPRs and LBRs in relation to u-hCG dosages
| Variable | u-hCG | |||
|---|---|---|---|---|
| 5000 (n=39) | 10000 (n=193) | 15000 (n=63) | P value | |
| BMI | 27.0 ± 5.7 | 27.8 ± 6.5 | 26.0 ± 6.1 | 0.11 |
| Serum hCG (IU) 12-14 hours after hCG trigger | 129.2 ± 10.1c | 229.2 ± 8.5b | 394.0 ± 27.0a | 0.001 |
| Gn. stimulation (days) | 10.4 ± 0.3 | 10.2 ± 0.1 | 10.6 ± 0.2 | NS |
| Total Gn dose (IU) | 4019.6 ± 551.0 | 5150.1 ± 246.0 | 5218.5 ± 429.3 | NS |
| Total follicles developed | 30.7 ± 1.6a | 18.6 ± 0.7b | 19.5 ± 1.2b | 0.001 |
| Follicles ≥14 mm day of hCG | 17.1 ± 0.9a | 10.2 ± 0.3b | 10.2 ± 0.6b | 0.001 |
| E2 day of hCG (pg/mL) | 3981 ± 88.0a | 2293.5 ± 57.1b | 1930 ± 80.9c | 0.001 |
| Endometrium thickness on day of hCG (mm) | 10.7 ± 0.4 | 10.4 ± 0.2 | 10.5 ± 0.3 | NS |
| Oocytes collected | 22.6 ± 1.6a | 13.4 ± 0.6b | 11.4 ± 0.8b | 0.001 |
| Mature oocytes | 18.8 ± 1.0a | 10.5 ± 0.5b | 9.0 ± 0.6b | 0.001 |
| Oocytes fertilized | 14.8 ± 0.9a | 8.2 ± 0.4b | 7.2 ± 0.5b | 0.001 |
| Embryos transferred | 2.5 ± 0.1 | 2.7 ± 0.1 | 2.6 ± 0.1 | NS |
| CPR (%) | 17/39 (43.6) | 79/193 (40.9) | 28/63 (44.4) | NS |
| LBR (%), n=292* | 16/39 (41.0) | 67/190 (35.3) | 25/63 (39.7) | NS |
Except otherwise stated results are means ± SE from two-way ANOVAs with Tukey post hoc analysis as appropriate. No interactions were detected between BMI and hCG. Different letters denote differences among groups (a vs. b, a vs.c, and b vs. c; P<0.05). BMI; Body mass index, u-hCG; Urinary derived human chorionic gonadotropin, Gn; Gonadotropin, E2; Estradiol; CPR; Clinical pregnancy rate, LBR; Live birth rate; NS; Nonsignificant, and *; 3 cycles were lost to follow up hence the outcome of pregnancy in these 3 cases was not known.