Table 1.

Biomarkers and carbon monoxide verified abstinence by gender and randomization.

			Men				Women

			Gum		Snus		Gum		Snus

Carbon Monoxide –Confirmed Abstinence			N	%	N	%	N	%	N	%	Interaction p-value^a

Point Prevalence
Week 12			29	29.0	23	21.5	19	20.0	20	22.5	0.21
Week 26			22	22.0	12	11.2	8	8.4	10	11.2	0.07
Continuous Cigarette Avoidance
Week 12			15	15.0	6	5.6	4	4.2	5	5.6	0.09
Week 26			9	9.0	3	2.8	1	1.1	2	2.3	0.16
	Men					Women

	Gum		Snus			Gum			Snus

Biomarkers	N	Mean (SD)	N	Mean (SD)		N	Mean (SD)		N	Mean (SD)	Interaction p-value^b

Total Cotinine^c
Baseline	98	3845 (2018)	106	3291 (2358)		94	3325 (2269)		89	3506 (2207)	0.22
Week 4	80	2665 (2487)	86	2686 (2109)		77	2405 (2074)		67	2849 (2550)	0.08
Total Nicotine Equivalents^c
Baseline	98	69.3 (38.2)	106	62.1 (43.3)		94	63.8 (45.6)		89	71.0 (52.0)	0.78
Week 4	80	46.4 (44.5)	86	48.9 (41.9)		77	44.4 (40.3)		67	48.5 (38.5)	0.03
Total NNAL^d
Baseline	80	1.31 (1.02)	87	1.37 (1.53)		78	1.68 (1.21)		68	1.46 (1.06)	0.004
Week 4	79	0.67 (0.83)	85	1.37 (1.52)		76	1.04 (1.28)		65	1.60 (1.65)	0.26

P-values for gender by randomization interaction are adjusted for gender, randomization, and baseline cigarettes per day.

Baseline p-value for gender differences are adjusted for site and baseline cigarettes per day. Week 4 p-value for gender by randomization interaction are adjusted forbaseline value, gender, randomization, study site and baseline cigarettes per day.

nmol/ml.

pmol/mg creatinine; only available among those who completed study visit at week 4.