Table 2.
Description and summary statistics of microparticles and immune cells and regression coefficients for PM2.5 from the subject-mean adjusted regression models.
| Outcome variables | Phenotype | No. of obs. | Mean* | Std. Dev. | Coefficient (x 10) (Std. Error) | P-value | R2 |
|---|---|---|---|---|---|---|---|
| Microparticles | |||||||
| MP, EPC | CD34+/CD31+ | 332 | 22.03 | 21.68 | −0.09 (0.34) | 0.796 | 0.00 |
| MP, Platelet | CD41+ | 332 | 37.37 | 34.94 | −1.33 (0.55) | 0.017 | 0.02 |
| MP, Endothelial | CD31+/CD41− | 332 | 6.76 | 10.14 | 1.00 (0.16) | <0.001 | 0.11 |
| MP, Lung Endothelial | CD31+/CD41−/CD143+ | 331 | 2.82 | 4.48 | 0.42 (0.07) | <0.001 | 0.10 |
| MP, Non-lung Endothelial | CD31+/CD41−/CD143− | 331 | 3.88 | 6.40 | 0.56 (0.10) | <0.001 | 0.09 |
| MP, Venous Endothelial | CD31+/CD41−/EphB4+ | 329 | 2.55 | 5.54 | 0.48 (0.09) | <0.001 | 0.09 |
| MP, Lung Venous Endothelial | CD31+/CD41−/EphB4+/CD143+ | 329 | 2.06 | 4.57 | 0.39 (0.07) | <0.001 | 0.08 |
| MP, Arterial Endothelial | CD31+/CD41−/EphrinB2+ | 331 | 3.68 | 5.03 | 0.37 (0.07) | <0.001 | 0.07 |
| MP, Lung Arterial Endothelial | CD31+/CD41−/EphrinB2+/CD143+ | 331 | 3.27 | 4.56 | 0.31 (0.07) | <0.001 | 0.06 |
| MP, Activated Endothelial | CD62+ | 332 | 17.91 | 16.11 | −0.63 (0.26) | 0.014 | 0.02 |
| MP, Lung Activated Endothelial | CD62+/CD143+ | 332 | 3.93 | 4.25 | 0.005 (0.06) | 0.943 | 0.00 |
| MP, Venous Activated Endothelial | CD62+/EphB4+ | 332 | 4.40 | 6.67 | −0.02 (0.10) | 0.876 | 0.00 |
| MP, Lung Venous Activated Endothelial | CD62+/EphB4+/CD143+ | 329 | 3.57 | 3.80 | −0.002 (0.06) | 0.980 | 0.00 |
| MP, Arterial Activated Endothelial | CD62+/EphrinB2+ | 330 | 5.17 | 5.03 | 0.03 (0.08) | 0.702 | 0.00 |
| MP, Lung Arterial Activated Endothelial | CD62+/EphrinB2+/CD143+ | 330 | 4.52 | 4.47 | 0.05 (0.07) | 0.518 | 0.00 |
| Immune cells | |||||||
| Monocytes | CD14+ | 365 | 22,503 | 15,535 | 863.99 (185.95) | <0.001 | 0.06 |
| Natural killer cells | CD16+ | 365 | 17,530 | 16,784 | 660.22 (182.24) | <0.001 | 0.03 |
| Helper T cells | CD4+ | 365 | 72,604 | 42,633 | 2151.75 (504.36) | <0.001 | 0.05 |
| Killer T cells | CD8+ | 365 | 39,259 | 24,421 | 1038.21 (323.52) | 0.001 | 0.03 |
| B cells | CD19+ | 365 | 18,242 | 22,527 | −310.72 (304.33) | 0.308 | 0.00 |
| Platelet-monocyte aggregates | CD45+/CD41+ | 368 | 4.71 | 5.62 | 0.20 (0.09) | 0.020 | 0.01 |
*
Per volume of the analytical tube. All microparticle subpopulations were <1 μm and AnnexinV+