Table 2. Genotypic frequencies and overall association of genetic variants in SOD2 and GPX1 with Crohn’s disease and ulcerative colitis.
| Locus | Model | Controls n = 434 | Crohn’s disease n = 436 | OR (95% CI) | P-value | P-value adjusted | Ulcerative colitis n = 367 | OR (95% CI) | P-value | P-value adjusted |
|---|---|---|---|---|---|---|---|---|---|---|
| SOD2 rs4880 | n = 426 | n = 435 | n = 367 | |||||||
| AA* | 119 (27.9) | 142 (32.6) | 1.00 | 102 (27.8) | 1.00 | |||||
| GA | 198 (46.5) | 214 (49.2) | 0.79 (0.55–1.13) | 0.193 | 1.00 | 184 (50.1) | 1.07 (0.75–1.51) | 0.700 | 1.00 | |
| GG | 109 (25.6) | 79 (18.2) | 0.57 (0.37–0.89) | 0.013 | 0.077 | 81 (22.1) | 0.89 (0.59–1.34) | 0.547 | 1.00 | |
| A carrier* vs. GG | 317 (74.4)/109 (25.6) | 356 (81.8)/79 (18.2) | 0.66 (0.45–0.97) | 0.033 | 0.197 | 286 (77.9)/81 (22.1) | 0.85 (0.60–1.20) | 0.366 | 1.00 | |
| GPX1 rs1050450 | n = 428 | n = 430 | n = 367 | |||||||
| GG* | 199 (46.5) | 191 (44.4) | 1.00 | 146 (39.8) | 1.00 | |||||
| GA | 187 (43.7) | 187 (43.5) | 0.96 (0.69–1.34) | 0.802 | 1.00 | 164 (44.7) | 1.18 (0.86–1.61) | 0.277 | 1.00 | |
| AA | 42 (9.8) | 52 (12.1) | 1.39 (0.80–2.40) | 0.242 | 1.00 | 57 (15.5) | 1.93 (1.20–3.12) | 0.006 | 0.037 | |
| G carrier* vs. AA | 386 (90.2)/42 (9.8) | 378 (87.9)/52 (12.1) | 1.39 (0.83–1.38) | 0.210 | 1.00 | 310 (84.5)/57 (15.5) | 1.78 (1.13–2.80) | 0.012 | 0.070 |
* Reference;
ORs and 95% CIs were calculated considering the codominant and recessive models, adjusted for gender and age; bold font indicates nominally significant results; p-value cutoff = 0.0083 (after Bonferroni correction applied separately to each disease group); SNPs were genotyped on the complementary DNA strand.