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Processes and mediators involved in carcinogenesis that likely lead to cancer pain
| Carcinogenesis process | Algogenic mediators involved with carcinogenesis |
|---|---|
| Cancer proliferation | ATP, protons |
| Tissue invasion and metastasis | proteases |
| Perineural invasion | proteases |
| Angiogenesis | ET-1, bradykinin, neurotrophins |
| Neurogenesis within cancer microenvironment | neurotrophins |
