Table 1.
Patient Laboratory Data.*
| Immunologic Finding | Normal Range for Infants |
Value in Patient at 20 Days of Age |
Value in Patient at 2 Yr of Age† |
|---|---|---|---|
| TRECs per microliter/β-actin copies per microliter | >25/>10,000 | 0/68,900‡ | |
| White-cell count (cells/µl) | 9000–30,000 | 9500 | 12,700 |
| Platelet count (platelets/µl) | >150,000 | 333,000 | 337,000 |
| Neutrophil count (cells/µl) | >1500 | 4900 | 6630 |
| Total lymphocyte count (cells/µl) | >2600 | 2600 | 4590 |
| Eosinophil count (cells/µl) | <800 | 600 | 660 |
| CD3+ T-cell count (cells/µl) | 2250–5500 | 182‡ | 2157 |
| CD4+ helper T-cell count (cells/µl) | >1600 | 130‡ | 1239 |
| CD8+ cytotoxic T-cell count (cells/µl) | >560 | 26‡ | 826 |
| CD19+ B-cell count (cells/µl) | 300–2000 | 1326 | 1652 |
| CD16+/CD56+ NK cell count (cells/µl) | 170–1100 | 468 | 643 |
| CD3+/CD4+/CD45RA+ naive cells (% of CD4+) | >50 | Undetectable‡ | 44 |
| CD3+/CD8+/CD45RA+ naive cells (% of CD8+) | >30 | 19‡ | 40 |
| CD45+ lymphocytes proliferating in response to PHA (%)‡ | >50 | 18‡ | 100 |
| CD3+ T cells proliferating in response to PHA (%) | >58 | 43‡ | 100 |
| IgG concentration (mg/dl) | 345–1213 | 1050 | |
| IgA concentration (mg/dl) | 14–159 | 52 | |
| IgM concentration (mg/dl) | 43–200 | 100 | |
| IgE concentration (IU/ml) | 370 | ||
| Antipneumococcal antibodies, 14 serotypes | 12/14 protective | ||
| Antitetanus antibody (IU/ml) | >0.5 | 2.73 |
*
NK denotes natural killer, PHA phytohemagglutinin, and TREC T-cell–receptor excision circle.
†
The patient had undergone hematopoietic cell transplantation and vaccination and was receiving no medications or immune globulin.
‡
Value is abnormal.