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. Author manuscript; available in PMC: 2017 Mar 15.
Published in final edited form as: J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 9;1015-1016:34–41. doi: 10.1016/j.jchromb.2016.02.012

Table 3.

Extraction recovery, intra-day and inter-day precision, and matrix effects for irinotecan, SN-38 and SN-38 glucuronide in liver homogenate using MRM method (n=6)

Compound Conc.
(nM)
Extraction recovery
Average ± SD (%)
Intra-day Inter-day Matrix effect
Average ± SD (%)

Accuracy
(bias, %)
Precision
(CV, %)
Accuracy
(bias, %)
Precision
(CV, %)
40 92.09 ± 8.11 93.87 2.89 91.01 0.22 101.01 ± 12
CPT-11 200 83.94 ± 5.65 95.04 5.97 103.50 0.13 95.97 ± 10.9
1000 82.26 ± 4.38 91.55 2.66 107.77 0.94 96.3 ± 3
40 80.28 ± 0.92 92.21 6.58 97.49 0.23 96.16 ± 5.4
SN-38 200 80.58 ± 3.64 95.39 3.46 97.94 0.34 84.23 ± 3.13
1000 83.88 ± 5.98 96.75 3.74 97.53 2.19 95 ± 9.18
8 111.56 ± 4.75 96.04 2.75 108.4 0.01 91.96 ± 10.55
SN-38G 40 95.51 ± 1.05 87.46 4.18 98.32 0.08 84.85 ± 3.95
200 84.9 ± 3.62 95.16 3.26 98.43 0.42 97.41 ± 0.98