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. 2016 Dec 19;12(12):e1006521. doi: 10.1371/journal.pgen.1006521

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© 2016 Sulaiman et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 6 — A-B, Ventral views of mutant embryos at E17.5. The left forelimb is severely truncated compared to the right in Tbx5^lox/lox;Prx1Cre;Prx1-Tbx mutant (arrow) (A). Tbx5^lox/lox;Prx1Cre;Prx1-Tbx;Z/EGFgf10 mutant lacks digit one in the left forelimb (arrow) (B). C-E, Skeletal preparation of Tbx5^lox/lox;Prx1Cre;Prx1-Tbx (C), Tbx5^lox/lox;Prx1Cre;Prx1-Tbx;Z/EGFgf10 (D) and control (E) forelimbs. Left forelimbs are more severely affected than right in both examples. Absent digit 1 (thumb) (arrow), bifurcated digit (arrowheads).