. Author manuscript; available in PMC: 2017 Dec 1.

Published in final edited form as: Cancer Metastasis Rev. 2016 Dec;35(4):601–629. doi: 10.1007/s10555-016-9643-z

Table 3.

The role of myeloid-derived suppressor cells (MDSC) in breast cancer

Role	Identification Isolation	Tumor model	Experimental system Species	Reference
Angiogenesis	FC: CD11b+ Gr1+	4T1	Mouse, In vivo	271
Invasion	FC: CD11b+ Gr1+	MMTV-PyVmT/Tgfbr2^MGKO, 4T1	Mouse, In vivo	272
Metastasis	IF: Gr1+ FC: CD11b+ Gr1+ (CD11b+ Ly6C high)	MMTV-PyMT MDA-MB-231	Mouse, In vivo Human, In vivo Human patient samples	275
	FC: CD11b+ Gr1+	4T1	Mouse, In vivo	279
	FC: CD11b+ Ly6Cmed Ly6G+	E0771, MMTV-PyMT	Mouse, In vivo	280
	FC: CD11b+ Gr1+	4T1	Mouse, In vivo	295
Immunosuppression	FC: CD11b+ Gr1+	4T1	Mouse, In vivo	139
	FC: CD11b+ Gr1+	4T1	Mouse, In vivo	258
	FC: CD11b+ Gr1+	4T1, DA-3, D1-DMBA-3	Mouse, In vivo	259
	FC: CD11b+ Gr1+	4T1	Mouse, In vivo	263
Cancer stem cell-ness	IF: S100A8 FC: CD11b+ Ly6G+ Ly6C low-med	67NR, 4T07, 4T1, P53-null tumor models, MMTV-Wnt1, MMTV-Wnt1- iFGFR, p53 pten −/−	Mouse, In vivo Human, In vitro Human, In vivo (patient-derived xenografts)	291