Table 4.
The glucose metabolism‐associated pathways identified by GO and KEGG pathway analysis using potential targets of microRNAs upregulated by both low‐ and high‐dose TAC
| ID | Name | Enrichment score | p‐value | FDR | Gene symbols |
|---|---|---|---|---|---|
| GO analysis | |||||
| 0006006 | Glucose metabolic process | 4.327 | 5.91E‐08 | 4.09E‐06 | PGAM1, GPI, PGM1, BRS3, PRKACA, PKLR, SERP1, KCNJ11, TNF, PFKFB2, PFKM, AKT2, PHKG2, PFKFB4, ADIPOQ, GYG2, IGFBP5, CALM1, IRS2, WDTC1 |
| 0042593 | Glucose homeostasis | 3.938 | 4.42 × 10−5 | 1.08 × 10−3 | TCF7L2, STAT3, MLXIPL, RPH3AL, IGFBP5, PFKM, ADIPOQ, PRKAA2, HNF4A, NGFR, SLC2A4, NCOR2, CACNA1E |
| 0008286 | Insulin receptor signaling pathway | 3.684 | 6.87 × 10−8 | 4.51 × 10−6 | IRS2, FOXC2, TSC1, FOXO4, PRKAA2, NAMPT, AKT2, EIF4G1, NRAS, PIK3R1, MAPK1, IDE, SOCS7, EEF2K, PRKAB2, PRKAG1, EIF4B, PDPK1, IGF1R, APPL1, STXBP4, FOXO1, FGFR1, EIF4EBP2 |
| 0046326 | Positive regulation of glucose import | 7.573 | 2.78 × 10−6 | 1.10 × 10−4 | PRKCD, GPC3, AKT2, PIK3R1, ARPP19, CREBL2, PRKCI, IRS2, ADIPOQ |
| 0009749 | Response to glucose stimulus | 4.309 | 7.87 × 10−5 | 1.70 × 10−3 | HNF4A, PRKCD, THBS1, TCF7L2, ADIPOQ, NNAT, ACVR2B, IRS2, PFKFB2, VAMP2, PKLR |
| 0032869 | Cellular response to insulin stimulus | 5.274 | 1.44 × 10−6 | 6.35 × 10−5 | SLC2A4, ACSL6, ADIPOQ, PKLR, AKT2, PRKCI, PDPK1, PRKCD, HDAC9, IRS2, VAMP2, PAK1, WDTC1 |
| KEGG pathway analysis | |||||
| 04910 | Insulin signaling pathway | 4.219 | 9.39 × 10−10 | 1.42 × 10−8 | SOCS4, PHKG2, CALM3, IRS2, ACACA, RAPGEF1, PKLR, AKT3, PRKACA, PDPK1, PRKAB2, PIK3R1, CBL, CALM1, AKT2, SLC2A4, FOXO1, GSK3B, PPP1R3D, PRKAA2, NRAS, PRKAG1, MAPK1, ELK1, PRKCI, TSC1 |
GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; TAC, tacrolimus; FDR, false discovery rate.