Table 3.

Combinations, of two or more positive biomarkers, predict higher risk for asthma development at age 6 and age 11. Utilizing the data from the children in the cohort who had data on all biomarkers, we assessed the utility of combinations of biomarkers. ORs are reported with associated 95% CI comparing none, only one and any two as it relates to development at age 6 and 11.

Asthma at age 6
		Asthma		OR(95% CI)
	N(%)	6	N(%)	vs. None	vs. Only one
None	68(35%)	Yes	14(21%)	Ref
		No	54(79%)
Only one	90(46%)	Yes	20(22%)	1.1 (0.5, 2.4)	Ref
		No	70(78%)
Any two or more	38(19%)	Yes	24(63%)	6.6 (2.7, 16.0)	6.0 (2.6, 13.7)
		No	14(37%)
Asthma at age 11
		Asthma		OR(95% CI)
	N(%)	11	N(%)	vs. None	vs. Only one
None	58(34%)	Yes	15(26%)	Ref
		No	43(74%)
Only one	78(46%)	Yes	20(26%)	1.0 (0.5, 2.2)	Ref
		No	58(74%)
Any two or more	34(19%)	Yes	18(53%)	3.2 (1.3, 7.9)	3.3 (1.4, 7.6)
		No	16(47%)