Table 3.
Comparing patients with MRONJ between MM stages according to each factor (sign, location, etiologic factor, BP type, treatment, and outcome) of MM
| Stage | ||||
|---|---|---|---|---|
| 1 | 2 | 3 | P value | |
| Number of patients | 2 | 6 | 1 | |
| Location (%) | 1 | |||
| Mandible | 2 (100) | 5 (83.33) | 1 (100) | |
| Maxilla | 0 (0) | 1 (16.67) | 0 (0) | |
| Infection (%) | 0.0476* | |||
| Yes | 0 (0) | 5 (83.33) | 0 (0) | |
| No | 2 (100) | 1 (16.67) | 1 (100) | |
| Etiology (%) | 0.7222 | |||
| Extraction | 1 (50) | 3 (50) | 1 (100) | |
| Prosthesis problem | 0 (0) | 2 (33.33) | 0 (0) | |
| Periodontal problem | 0 (0) | 1 (16.67) | 0 (0) | |
| Spontaneous | 1 (50) | 0 (0) | 0 (0) | |
| Bisphosphonate type (%) | 0.25 | |||
| Combinationa | 2 (100) | 5 (83.33) | 0 (0) | |
| Only zoledronate | 0 (0) | 1 (16.67) | 0 (0) | |
| Only pamidronate | 0 (0) | 0 (0) | 1 (100) | |
| Treatmentb (%) | 0.6429 | |||
| Conservative | 2 (100) | 3 (50) | 1 (100) | |
| Invasive | 0 (0) | 3 (50) | 0 (0) | |
| Outcome (%) | 1 | |||
| 1 | 1 (100) | 4 (80) | 0 (0) | |
| 2 | 0 (0) | 1 (20) | 0 (0) | |
| Duration in months | 21 (17–25) | 19 (11–69) | 9 (9–9) | 0.2992 |
Categorical variables such as sign, location, etiologic factor, BP type, treatment, and outcome were analyzed by Fisher’s exact test. Continuous variables such as duration were analyzed by Wilcoxon test
*Statistically significant (p value <0.05)
aCombination of zoledronate and pamidronate
bConservative: antibiotic therapy and dressing invasive: biopsy or saucerization