Table 3.

Deterministic sensitivity analysis results, ISAV vs. VORI

Parameter	Total cost per patient		Incremental cost per death avoided		Incremental cost per clinical responder
	Low SA input	High SA input	Low SA input	High SA input	Low SA input	High SA input
Changing the inputs for both ISAV and VORI
Treatment duration (IV)	−$7173.91	−$7661.64	Dominant	Dominant	Dominant	Dominant
Treatment duration (oral)	−$7703.00	−$7132.55	Dominant	Dominant	Dominant	Dominant
Total treatment duration	−$7522.57	−$7312.98	Dominant	Dominant	Dominant	Dominant
Initial hospital length of stay (±25.0%)	−$6161.21	−$8674.34	Dominant	Dominant	Dominant	Dominant
Initial hospital length of stay (mean values)	−$2200.00		Dominant		Dominant
Readmission length of stay	−$7151.85	−$7683.70	Dominant	Dominant	Dominant	Dominant
Readmission rate	−$7327.91	−$7484.42	Dominant	Dominant	Dominant	Dominant
Per diem cost of hospitalization	−$5702.70	−$9132.86	Dominant	Dominant	Dominant	Dominant
Total cost of AEs	−$7352.95	−$7482.61	Dominant	Dominant	Dominant	Dominant
Drug prices (IV and oral)	−$7343.24	−$7492.31	Dominant	Dominant	Dominant	Dominant
Payer perspective	−$4833.26		Dominant		Dominant
Equal initial length of stay, mortality rate, and clinical response rate	−$1411.05		–		–
Mortality rate	–	–	Dominant	Dominant	Dominant	Dominant
Clinical response rate	–	–	Dominant	Dominant	Dominant	Dominant
Changing the inputs for ISAV only
Initial hospital length of stay	−$17,295.94	$2460.39	Dominant	$158,459.35	Dominant	$143,398.88
Readmission rate	−$8216.44	−$6477.45	Dominant	Dominant	Dominant	Dominant
Mortality rate	–	–	Dominant	$198,126.42	–	–
Clinical response rate	–	–	–	–	$106,054.92	Dominant

ISAV isavuconazole, VORI voriconazole, IV intravenous, AE adverse event