Table 1. Biometric and echocardiographic parameters of wild-type (WT) and Md2−/− (KO) mice fed control or high-fat diet for 4 months.
| Parameter | B6-Con (N=8) | B6-HFD (N=8) | KO-Con (N=8) | KO-HFD (N=8) |
|---|---|---|---|---|
| Heart rate (bmp) | 469.8±34.76 | 492.4±20.8 | 445.6±25.85 | 460.0±46.50 |
| Fractional shortening (%) | 41.92±0.75 | 38.13±1.34* | 43.30±1.02 | 40.18±0.82# |
| LVEF (%) | 79.38±0.79 | 67.98±1.21* | 78.10±1.52 | 77.62±1.10# |
| LVID d (mm) | 3.02±0.05 | 3.37±0.06* | 3.22±0.06 | 3.38±0.08 |
| LVID s (mm) | 1.78±0.05 | 2.21±0.06* | 1.85±0.08 | 1.88±0.05# |
| LVPW d (mm) | 0.91±0.005 | 0.96±0.004 | 0.88±0.010 | 0.91±0.008 |
| LVPW s (mm) | 1.02±0.007 | 1.15±0.02* | 1.04±0.01 | 1.05±0.01# |
| LVFW d (mm) | 0.91±0.01 | 0.97±0.007* | 0.90±0.01 | 0.91±0.01# |
| LVFW s (mm) | 1.08±0.005 | 1.15±0.013* | 1.03±0.014 | 1.07±0.016# |
| IVS d (mm) | 0.92±0.013 | 0.95±0.006 | 0.88±0.008 | 0.90±0.013# |
| IVS s (mm) | 1.07±0.003 | 1.16±0.016* | 1.03±0.012 | 1.04±0.024# |
ANOVA, analysis of variance; HFD, high-fat diet; IVS, interventricular septum; d, diastolic; KO, knockdout; LFFW, left ventricle free wall; LVEF, left ventricle ejection fraction; LVID, left ventricle internal dimension; LVPW, left ventricle posterior wall; s, systolic.
Data are reported as mean±s.e. and analysed by one-way ANOVA, *P<0.05 versus B6-LF group; #P<0.05 versus B6-HFD group.