Table 2.

Multivariate analysis identifying factors associated with rapid cognitive decline at 12 months

	Odds ratio [95% CI]	p
Immediate family caregiver (spouse or child of patient)	0.27 [0.26–0.28]	<0.0001
Autonomy for washing (ADL)	0.45 [0.44–0.46)	<0.0001
Polymedication	0.61 [0.60–0.62]	<0.0001
Presence of caregiver burden	3.50 [3.40–3.60]	<0.0001

Variables proposed in multivariate analysis were immediate family caregiver, autonomy for washing (ADL), polymedication, presence of caregiver burden, baseline MMSE score, the “positive affect/humour” domain of the Dementia Quality of Life, high school diploma or higher education, attending day care centre, disinhibition, irritability, autonomy for dressing (ADL), ability to do shopping and ability to manage own treatment (IADL). CI, confidence interval; ADL, Activities of Daily Living; IADL, Instrumental Activities of Daily Living.