Table 2.
Results (unadjusted) of cognitive tests and MRI
| Controls (n = 58) | SMC (n = 25) | AUC (95% CI) SMC/controls | MCI (n = 115) | AUC (95% CI) MCI/controls | |
|---|---|---|---|---|---|
| MMSE | 29.0 (28.0–30.0) | 27.0 (27.0–29.0)a | 27.0 (26.0–28.0)b | ||
| Word test part 1 | 7.8 (1.6) | 6.9 (1.3)b | 5.4 (1.7)d | ||
| Word test part 2 | 22.0 (20.0–24.0) | 20.0 (16.0–22.0)b | 20.0 (16.0–22.0)a | ||
| DST | 39.6 (10.6) | 29.8 (11.1)ae | 25.7 (9.0)b | ||
| Trail A | 36.9 (11.4) | 48.6 (16.9)ce | 57.1 (23.2)b | ||
| Trail B | 92.4 (36.0) | 141.8 (61.2)a | 162.8 (64.2)b | ||
| Finger-tapping test | 51.6 (8.2) | 47.2 (8.7)b | 40.5 (11.7)d | ||
| IQCODE | 3.0 (3.0–3.0) | 3.2 (3.1–3.3)b | 3.1 (3.0–3.3)b | ||
| Clock-drawing test | 7.0 (6.8–7.0) | 6.0 (6.0–7.0)b | 6.0 (5.8–7.0)a | ||
| RDRS2 | 21.0 (21.0–22.0) | 23.5 (22.0–25.0)b | 23.0 (22.0–25.0)b | ||
| MADRS | 1.0 (1.0–2.0) | 3.0 (1.0–5.5)a | 2.0 (1.0–5.0)b | ||
| BMD cognitiong | 49.0 (47.0–52.0) | 50.0 (44.5–51.0) | 48.0 (44.0–52.0)b | ||
| BMD behaviorg | 2.0 (0.00–5.00) | 6.0 (2.5–10.0)ad | 3.0 (0.00–8.00) | ||
| Hippocampush | 0.50 (0.04) | 0.48 (0.06)b | 0.67 (0.52–0.81) | 0.48 (0.05)b | 0.60 (0.52–0.69) |
| Amygdalah | 0.22 (0.02) | 0.21 (0.02) | 0.53 (0.40–0.66) | 0.20 (0.03)b | 0.65 (0.56–0.73) |
| Lateral ventricleh | 2.00 (1.53–3.18) | 2.46 (1.87–3.18) | 0.61 (0.48–0.74) | 2.51 (2.03–3.84)b | 0.66 (0.57–0.75) |
| Cerebral cortexh | 30.88 (1.65) | 30.49 (1.86) | 0.53 (0.39–0.67) | 30.24 (1.80)b | 0.59 (0.51–0.68) |
| Cerebral white matterh | 27.96 (2.34) | 27.81 (2.54) | 0.52 (0.38–0.65) | 27.26 (2.33)f | 0.59 (0.50–0.68) |
| Cerebrumh | 72.55 (2.89) | 71.78 (3.20) | 0.57 (0.44–0.71) | 70.98 (3.36)b | 0.64 (0.56–0.73) |
| WMHh | 0.002 (0.001–0.007) | 0.005 (0.001–0.015) | 0.59 (0.44–0.73) | 0.006 (0.002–0.016)b | 0.66 (0.57–0.74) |
Values are expressed as means (standard deviations) for continuous normally distributed variables and medians (interquartile ranges) for continuous skewed variables. Independent samples t test for continuous normally distributed variables and Mann-Whitney test for continuous skewed variables. AUC = Area under the curve (component of receiver operating characteristic curve); DST = digit symbol-coding test; WMH = white matter hyperintensities.
p < 0.001 compared to controls.
p < 0.00001 compared to controls.
p < 0.05 (2-tailed) compared with controls.
p < 0.05 (2-tailed) compared with controls and SMC.
p < 0.05 (1-tailed) compared with MCI.
p < 0.05 (1-tailed) compared with controls.
Greene et al.'s Behavior and Mood Disturbance scale.
Total ICV-corrected volumes = (sum of bilateral volumes × 100) divided by ICV.