Table 3.

Multivariate linear regression with volumes of cerebral structures as outcome variables.

	Adjusted for age and sex				Multivariable analysis
	β	95% CI	p	β	95% CI	p
Hippocampus
Age				−0.003	−0.004 to–0.002	<0.000001
Sexa				−0.021	−0.035 to–0.007	0.003
Probable parental LOADb	−0.018	−0.034 to–0.003	0.019	−0.015	−0.031 to 0.001	0.058
ApoE ɛ4c	−0.021	−0.033 to–0.008	0.001	−0.016	−0.029 to–0.003	0.015
Smoking (ever)	0.00004	−0.150 to 0.150	1.00	0.002	−0.012 to 0.016	0.83
BMI	0.002	0.000 to 0.003	0.036	0.001	−0.001 to 0.002	0.27
Hypertension (ever)	−0.005	−0.018 to 0.008	0.46	−0.003	−0.017 to 0.011	0.69
Systolic BP (mm Hg)	0.0001	0.0002 to 0.0004	0.42	0.0002	−0.0001 to 0.001	0.23
Total cholesterol (mmol)	0.006	0.000 to 0.011	0.049	0.007	0.001 to 0.013	0.015
Diabetes (ever)	−0.0001	−0.026 to 0.025	0.99	−0.0003	−0.033 to 0.033	0.99
HbA1c (%)	0.005	−0.005 to 0.015	0.35	0.005	−0.007 to 0.018	0.38
eGFR (ml/min/1.73 m2)	−0.0004	−0.001 to 0.0002	0.17	−0.001	−0.001 to–0.00002	0.045
Cobalamin (pmol)	0.00003	−0.00001 to 0.00007	0.15	0.000006	−0.00004 to 0.00005	0.78
Folic acid (nmol)	0.0004	−0.0005 to 0.001	0.41	−0.0004	−0.001 to 0.001	0.39
tHcy (μmol)	−0.002	−0.003 to–0.004	0.010	−0.002	−0.004 to–0.001	0.004
Amygdala*
BMI	0.001	0.0004 to 0.002	0.003	0.001	0.0003 to 0.002	0.008
Total cholesterol (mmol)	0.002	−0.001 to 0.005	0.22	0.004	0.0004 to 0.007	0.029
tHcy (μmol)	−0.001	−0.001 to 0.0001	0.10	−0.001	−0.002 to–0.0001	0.028
Cerebral cortex*
eGFR (ml/min/1.73 m2)	−0.015	−0.036 to 0.006	0.16	−0.028	−0.050 to–0.005	0.016
Folic acid (nmol)	−0.021	−0.052 to 0.010	0.19	−0.047	−0.084 to–0.010	0.013
tHcy (µmol)	−0.022	−0.067 to 0.023	0.34	−0.080	−0.137 to–0.024	0.006
Cerebrum*
Total cholesterol (mmol)	0.004	0.00009 to 0.007	0.045	0.004	0.001 to 0.008	0.023
eGFR (ml/min/1.73 m2)	−0.0001	−0.0005 to 0.0002	0.46	−0.0004	−0.001 to–0.00004	0.030
Folic acid (nmol)	−0.0003	−0.001 to–0.0002	0.21	−0.001	−0.001 to–0.0002	0.013
tHcy (μmol)	−0.0005	−0.001 to 0.0003	0.19	−0.001	−0.002 to–0.0004	0.006
LnLateral ventricle*
Total cholesterol (mmol)	−0.024	−0.044 to–0.003	0.25	−0.030	−0.052 to–0.008	0.007
Diabetes (ever)	0.093	0.001 to 0.184	0.047	0.135	0.012 to 0.257	0.031
tHcy (μmol)	0.005	0.0001 to 0.009	0.044	0.005	−0.0002 to 0.011	0.061

Adjusted for age and sex and in multivariable analysis. With cerebral white matter and cerebral WMH as outcome variables, there were no significant/borderline significant associations. All cerebral volumes are bilateral. BMI = Body mass index; BP = mean of the last two of three resting blood pressures; Ln = natural logarithm; WMH = white matter hyperintensities. Bold font = Significant/borderline significant.

^*Only variables which were significant/borderline significant in multivariate analysis are displayed.

^aFemale = 0 and male = 1.

^bNo parental LOAD = 0 and probable parental LOAD = 1.

^cNo ApoE ɛ4 alleles = 0 and presence of one or both ApoE ɛ4 alleles = 1.