Table 4.

Multivariate-adjusted^a linear regression analysis with hippocampal volume as outcome variable, stratified by sex and probable parental LOAD

	Female (n = 93)				Male (n = 105)
	β	95% CI	p	β	95% CI	p
Age	−0.003	−0.004 to–0.001	0.0002	−0.003	−0.004 to–0.001	0.0003
Probable parental LOADb	−0.032	−0.054 to–0.010	0.005	−0.005	−0.028 to 0.017	0.64
ApoE ɛ4c	−0.021	−0.038 to–0.003	0.024	−0.012	−0.031 to 0.007	0.22
eGFR (ml/min/1.73 m2)	−0.001	−0.002 to–0.00002	0.044	−0.0001	−0.001 to 0.001	0.75
Cobalamin (pmol)	−0.000003	−0.00006 to 0.00006	0.93	0.00001	−0.00005 to 0.00007	0.78
Folic acid (nmol)	−0.001	−0.002 to 0.001	0.28	−0.001	−0.002 to 0.001	0.47
tHcy (μmol)	−0.002	−0.004 to–0.0003	0.021	−0.002	−0.004 to 0.001	0.15
	No LOAD (n = 156)	Probable parental LOAD (n = 42)
	β	95% CI	p	β	95% CI	p
Age	−0.003	−0.004 to–0.002	<0.000001	−0.001	−0.004 to 0.001	0.24
Sexd	−0.034	−0.048 to–0.020	<0.00001	−0.008	−0.036 to 0.020	0.55
ApoE ɛ4c	−0.019	−0.033 to–0.004	0.012	0.002	−0.026 to 0.030	0.89
eGFR (ml/min/1.73 m2)	−0.001	−0.001 to 0.00001	0.06	−0.0001	−0.001 to 0.001	0.85
Cobalamin (pmol)	−0.00002	−0.00008 to 0.00003	0.37	0.00006	−0.00002 to 0.0001	0.14
Folic acid (nmol)	−0.0002	−0.001 to 0.001	0.77	−0.002	−0.005 to–0.0001	0.039
tHcy (μmol)	−0.002	−0.003 to–0.0001	0.035	−0.005	−0.009 to–0.001	0.016

Bold font = Significant.

^aAdjusted for age, sex, probable parental LOAD, ApoE ɛ4, eGFR, cobalamin, folic acid, and tHcy.

^bNo parental LOAD = 0 and probable parental LOAD = 1.

^cNo ApoE ɛ4 alleles = 0 and presence of one or both ApoE ɛ4 alleles = 1.

^dFemale = 0 and male = 1.