Table 5. PAG functional connectivity co-varying with the present pain rating index of the primary dysmenorrheic subjects.
| Phase | Genotype | Region | BA | Cluster | t Score | Peak coordinate | ||
|---|---|---|---|---|---|---|---|---|
| x | y | z | ||||||
| Menstruation | G allele carriers | NA | NA | NS | NS | NA | NA | NA |
| Positive | ||||||||
| Menstruation | AA homozygotes | Insula | 13 | 11113 | 4.58 | 38 | −10 | 4 |
| Anterior cingulate cortex | 24 | — | 4.44 | −10 | 4 | 38 | ||
| Anterior cingulate cortex | 32 | — | 4.40 | −10 | 22 | 40 | ||
| Secondary somatosensory | 44 | — | 4.26 | 52 | 10 | 0 | ||
| Subthalamic nucleus | — | — | 4.05 | 12 | −16 | −8 | ||
| Cerebellum | — | — | 4.04 | −12 | −60 | −30 | ||
Peak coordinates refer to the Montreal Neurological Institute (MNI) space. Significance was thresholded at the uncorrected voxel level p = 0.005, followed by the FWE-corrected cluster level p = 0.05. BA, Brodmann area; mPFC, medial prefrontal cortex; NA, not available; NS, not significant.
*Four subjects with primary dysmenorrhea (3 AA homozygotes, 1 G allele carrier) did not complete the McGill Pain Questionnaire for present menstrual pain and were excluded from this calculation.