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. 2017 Jan 6;7:39692. doi: 10.1038/srep39692

Figure 2. Loss of TRIM14 contributes to NSCLC tumorigenicity in mice.

Figure 2

(a) NSCLC cells were injected into the left flanks of 6–8 week-old SCID mice (n = 7–10 animals per group). Exogenous TRIM14 expression in H3255 significantly suppressed tumor growth in H3255-bearing mice. (b) Final tumor weights were measured for each H3255 tumor-bearing mouse at necropsy (EV = empty vector control). (c–d) Downregulation of TRIM14 in H157 and H1650 cells (red and blue) significantly increased tumor growth in mice. (e) Final tumor weights were measured for each H1650 tumor-bearing mouse at endpoint. (Two-way mixed ANOVA analyses for tumor growth rates and two-tailed student’s t-test for final weight measurements, ****p < 0.0001).