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. 2017 Jan 6;7:40129. doi: 10.1038/srep40129

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(A) Sequencing results of MIP from unaffected and affected members of the family. The position of nucleotide substitution is indicated by a red arrow. (B) Phylogenetic conservation analysis. The result of a multiple-sequence alignment from various species showed that the Glycine at position 212 of MIP is highly conserved (marked in red). (C) A schematic diagram of the topology of MIP. Amino acid residue 212 is located within the 6th transmembrane domain (red circle).