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. 2017 Jan 6;7:39868. doi: 10.1038/srep39868

Figure 4. Inactivation of GSK3β/MEK1/2 signaling is not sufficient to block the effects of forcibly expressed cell surface syntaxin-4.

Figure 4

(a), Morphological changes by cell surface syntaxin-4 (ON) are apparently inhibited by PD0325901 and CHIR99021 (2i), inhibitors of GSK3β and MEK1/2, respectively. Bars, 50 μm. The lower photographs represent enlarged images of the insets of the upper images. Lower graph, quantification of cells with filopodia. N = 3, **p < 0.01, ***p < 0.001, n.s., not significant. (b), Syntaxin-4-triggered changes in the expression of p-cadherin, zscan4, and brachyury are not affected by 2i. N = 3, *p < 0.05.