Table 2. Association between TCF21, LPA, HHIPL1, RASD1–PEMT, MRPS6, CYP17A1-CNNM2-NT5C2, SMG6-SRR, PHACTR1, WDR12 and COL4A1-COL4A2 polymorphisms and CV events or subclinical atherosclerosis in patients with RA.
| Change | Presence/absence of CV events (n = 2,609) |
cIMT (n = 1,258) | Presence/absence of carotid plaques (n = 1,258) | |||
|---|---|---|---|---|---|---|
| P* | OR (95% CI)* | P† | P‡ | OR (95% CI)‡ | ||
| TCF21 rs12190287 | C/G | 0.32 | 0.87 (0.66–1.14) | 0.46 | 0.58 | 0.94 (0.77–1.15) |
| LPA rs3798220 | T/C | 0.15 | 1.90 (0.79–4.58) | 0.14 | 0.52 | 1.23 (0.65–2.36) |
| HHIPL1 rs2895811 | T/C | 0.79 | 1.03 (0.79–1.35) | 0.23 | 0.81 | 0.97 (0.79–1.19) |
| RASD1-PEMT rs12936587 | G/A | 0.53 | 1.08 (0.84–1.40) | 0.56 | 0.43 | 1.08 (0.89–1.31) |
| MRPS6 rs9982601 | C/T | 0.73 | 1.07 (0.71–1.61) | 0.53 | 0.59 | 0.92 (0.67–1.25) |
| CYP17A1-CNNM2-NT5C2 rs12413409 | G/A | 0.55 | 0.87 (0.56–1.36) | 0.24 | 0.67 | 1.07 (0.78–1.48) |
| SMG6-SRR rs216172 | G/C | 0.85 | 0.97 (0.75–1.27) | 0.14 | 0.31 | 0.90 (0.74–1.10) |
| PHACTR1 rs12526453 | C/G | 0.86 | 0.97 (0.74–1.27) | 0.83 | 0.19 | 1.14 (0.93–1.39) |
| WDR12 rs6725887 | T/C | 0.16 | 1.28 (0.90–1.82) | 0.08 | 0.24 | 0.85 (0.65–1.11) |
| COL4A1-COL4A2 rs4773144 | A/G | 0.93 | 1.01 (0.78–1.30) | 0.89 | 0.62 | 0.95 (0.78–1.15) |
CV: cardiovascular; RA: rheumatoid arthritis; cIMT: carotid intima-media thickness; OR: odds ratio; CI: confidence interval.
*Adjusted for sex, age at RA diagnosis, follow-up time and traditional CV risk factors using logistic regression.
†Adjusted for sex, age at the time of ultrasonography study, follow-up time and traditional CV risk factors using analysis of covariance (ANCOVA).
‡Adjusted for sex, age at the time of ultrasonography study, follow-up time and traditional CV risk factors by logistic regression.