Table 3. Association between ZHX2, LRIG1, PINX1, SLC17A4 and LDLR polymorphisms and CV events or subclinical atherosclerosis in patients with RA.
| Change | Presence/absence of CV events (n = 2,609) |
cIMT (n = 1,258) | Presence/absence of carotid plaques (n = 1,258) |
|||
|---|---|---|---|---|---|---|
| P* | OR (95% CI)* | P† | P‡ | OR (95% CI)‡ | ||
| ZHX2 rs11781551 | G/A | 0.96 | 1.00 (0.77–1.31) | 0.37 | 0.24 | 0.88 (0.72–1.08) |
| PINX1 rs6601530 | A/G | 0.42 | 0.90 (0.69–1.16) | 0.35 | 0.76 | 1.03 (0.85–1.25) |
| SLC17A4 rs4712972 | G/A | 0.07 | 1.41 (0.97–2.00) | 0.99 | 0.98 | 0.99 (0.75–1.31) |
| LRIG1 rs17045031 | G/A | 0.72 | 1.12 (0.59–2.12) | 0.35 | 0.42 | 0.81 (0.49–1.35) |
| LDLR rs6511720 | G/T | 0.25 | 0.81 (0.56–1.16) | 0.08 | 0.46 | 1.10 (0.85–1.44) |
CV: cardiovascular; RA: rheumatoid arthritis; cIMT: carotid intima-media thickness; OR: odds ratio; CI: confidence interval.
*Adjusted for sex, age at RA diagnosis, follow-up time and traditional CV risk factors using logistic regression.
†Adjusted for sex, age at the time of ultrasonography study, follow-up time and traditional CV risk factors using analysis of covariance (ANCOVA).
‡Adjusted for sex, age at the time of ultrasonography study, follow-up time and traditional CV risk factors by logistic regression.