FIG 3.

Proliferative responses of T-cell lines to peptides spanning A. centrale (Ac) OMP7 and A. marginale (Am) OMPs 7 to 9. Synthetic 30-amino-acid peptides overlapping by 10 amino acids were tested in triplicate for the induction of proliferation of 2-week T-cell lines from each indicated animal. The stimulation indices (SI) are indicated on the y axis, and the peptide number is indicated on the x axis. Results are presented only where there was a positive response to a peptide spanning one of the proteins. Asterisks indicate an SI of >4.0, which was considered to be significant. The results are representative of two or three separate assays for each animal.