TABLE 4.
Protection against B. burgdorferi challenge by passive immunization with monoclonal antibodies
| Antibody source | No. positive/total no. |
No. of mice positive/total no. | % mice protected | |||||
|---|---|---|---|---|---|---|---|---|
| Skin | Joint | Heart | Bladder | Ear | All sites | |||
| Normal mouse serum | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 15/15 | 3/3 | 0 |
| 1-5A10 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/25 | 0/5 | 100 |
| 1-8B7 | 0/5 | 1/5a | 0/5 | 0/5 | 0/5 | 1/25 | 1/5 | 80 |
| 2-8C10 | 0/5 | 0/5 | 0/5 | 0/5 | 0/5 | 0/25 | 0/5 | 100 |
| 2-2H8 | 5/5 | 3/3 | 5/5 | 5/5 | 5/5 | 23/23 | 5/5 | 0 |
| Serum pool M-OspCB31 | 3/3 | 3/3 | 3/3 | 3/3 | 3/3 | 15/15 | 3/3 | 0 |
| Serum pool D-OspCB31 | 1/5 | 1/5 | 1/5 | 1/5 | 1/5 | 5/25 | 1/5 | 80 |
a
Culture did not grow out, but spirochetes were observed in one field on day 7 attached to a fragment of tissue debris.