Table 2.
Unadjusted, fully adjusted and final models after ordered logistic regression of mRS at 6 months of potential predictors in 229 ESD Stroke Bergen study patients
| Predictor | Unadjusted model | Fully adjusted model (n=214) | Final model (n=223) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| LR test P‐value | LR test P‐value | |||||||||
| n | OR | 95% CI | P‐value | OR | 95% CI | OR | 95% CI | |||
| Premorbid variables: | ||||||||||
| Sex (female vs male) | 229 | 2.00 | (1.25, 3.20) | .004 | 2.28 | (1.27, 4.09) | .006 | 2.04 | (1.23, 3.39) | .006 |
| Age per 10 years | 229 | 1.71 | (1.40, 2.09) | <.001 | 1.33 | (0.94, 1.88) | .103 | 1.32 | (1.06, 1.64) | .012 |
| Previous cerebrovascular disease | 225 | 2.27 | (1.25, 4.13) | .007 | 1.82 | (0.85, 3.90) | .124 | 2.24 | (1.20, 4.16) | .011 |
| Previous coronary disease | 229 | 1.22 | (0.72, 2.08) | .454 | 1.21 | (0.61, 2.40) | .577 | |||
| Previous peripheral artery disease | 229 | 3.64 | (1.08, 12.3) | .037 | 3.06 | (0.80, 11.73) | .100 | 5.89 | (1.73, 20.00) | .004 |
| Previous hypertension | 229 | 1.92 | (1.20, 3.08) | .007 | 1.18 | (0.66, 2.09) | .578 | |||
| Previous diabetes | 228 | 1.40 | (0.73, 2.70) | .313 | 1.14 | (0.48, 2.72) | .765 | |||
| Previous atrial fibrillation, paroxystic | 229 | 1.24 | (0.56, 2.74) | .597 | 0.43 | (0.16, 1.12) | .084 | |||
| Previous atrial fibrillation, chronic | 229 | 2.27 | (0.89, 5.74) | .085 | 1.97 | (0.57, 6.84) | .285 | |||
| Previous smoking | 223 | 1.02 | (0.75, 1.39) | .903 | 1.27 | (0.87, 1.86) | .215 | |||
| Living with partner | 229 | 0.57 | (0.36, 0.92) | .021 | 0.80 | (0.44, 1.43) | .447 | |||
| In work before the stroke | 229 | 0.30 | (0.17, 0.52) | <.001 | 1.30 | (0.55, 3.08) | .549 | |||
| Stroke‐related variables: | ||||||||||
| Barthel Index at stable baseline per 5 points | 227 | 0.74 | (0.70, 0.78) | <.001 | 0.78 | (0.70, 0.85) | <.001 | 0.76 | (0.71, 0.81) | <.001 |
| NIHSS at stable baseline | 227 | 1.28 | (1.20, 1.36) | <.001 | 1.11 | (0.98, 1.26) | .094 | |||
| Haemorrhage vs infarction | 229 | 1.26 | (0.87, 1.84) | .227 | 0.89 | (0.56, 1.42) | .627 | |||
| Thrombolysis performed | 229 | 0.95 | (0.50, 1.82) | .883 | 0.54 | (0.25, 1.15) | 0.108 | |||
| Tube feeding necessary in acute phase | 229 | 16.4 | (6.91, 39.0) | <.001 | 3.81 | (1.10, 13.17) | .032 | 2.61 | (1.02, 6.72) | .044 |
| Urinary retention in acute phase | 229 | 2.10 | (1.29, 3.43) | .003 | 0.78 | (0.42, 1.44) | .423 | |||
| Urinary incontinence in acute phase | 229 | 6.53 | (3.54, 12.1) | <.001 | 1.03 | (0.48, 2.25) | .933 | |||
| Pneumonia in acute phase | 229 | 8.53 | (4.07, 17.9) | <.001 | 2.02 | (0.73, 5.61) | .176 | |||
| Urinary tract infection in acute phase | 229 | 3.80 | (1.95, 7.37) | <.001 | 1.68 | (0.71, 3.96) | .237 | |||
| Leukoaraiosis on CT or MRI | 229 | 2.61 | (1.62, 4.21) | <.001 | 1.82 | (0.97, 3.40) | .061 | |||
| Location of lesion | 229 | <.001 | .055 | |||||||
| Lacunar syndrome | 57 | 0.18 | (0.08, 0.41) | <.001 | 1.58 | (0.49, 5.07) | ||||
| Total anterior circulation syndrome | 30 | 1 | (reference) | 1 | (reference) | |||||
| Partial anterior circulation syndrome | 97 | 0.25 | (0.12, 0.51) | <.001 | 3.22 | (1.04, 9.98) | ||||
| Posterior circulation syndrome | 45 | 0.18 | (0.08, 0.43) | <.001 | 3.33 | (0.95, 11.6) | ||||
| Randomisation group | 229 | .408 | .137 | |||||||
| Day unit treatment | 81 | 0.69 | (0.38, 1.23) | .204 | 0.51 | (0.25, 1.02) | ||||
| Home treatment | 82 | 0.73 | (0.41, 1.30) | .291 | 0.80 | (0.40, 1.59) | ||||
| Control | 66 | 1 | (reference) | 1 | (reference) | |||||
| TOAST classification (infarctions only) | 202 | .073 | ||||||||
| Atherosclerosis | 22 | 0.81 | (0.35, 1.92) | .639 | ||||||
| Cardiac embolic | 69 | 1 | (reference) | |||||||
| Microangiopathy | 30 | 0.32 | (0.14, 0.70) | .004 | ||||||
| Others | 1 | 0.44 | (0.02, 8.27) | .586 | ||||||
| Unknown | 80 | 0.68 | (0.38, 1.22) | .197 | ||||||
| Subjective health complaints | 121 | 5.25 | (1.77, 15.55) | .003 | ||||||
| Estimated mRS before the stroke | 146 | 2.37 | (1.72, 3.27) | <.001 | ||||||
| Previous migraine | 179 | 0.60 | (0.33, 1.11) | .102 | ||||||
| Previous depression | 178 | 1.08 | (0.55, 2.09) | .825 | ||||||
| MMSE score at baseline | 104 | 0.87 | (0.81, 0.93) | <.001 | ||||||
ESD, early supported discharge; mRS, modified Rankin Scale; OR, Odds Ratio; CI, Confidence Interval; LR‐test, Likelihood ratio test; NIHSS, National Institutes of Health Stroke Scale; CT, Computerised Tomography; MRI, Magnetic Resonance Imaging; TOAST, Trial of Org 10172 in Acute Stroke Treatment4; MMSE, Mini Mental State Examination. P‐values ≤.05 indicated in bold.