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Compounds being developed for the treatment of NASH by targeting the gut immune system
| Compound | Description | Pre‐clinical data | Human triala |
|---|---|---|---|
| Liver‐extracted proteins | Fatty liver‐derived proteins | +77 | − |
| Anti‐CD3 | Anti‐CD3 antibodies | +76 | +119 |
| PRX106 | Anti TNF fusion protein | +124 | +a, 83 |
| Imm124E | Anti‐LPS antibodies | +109 | +123 |
| Glycosphingolipids | Glucosylceramide | +90, 91, 92 | +125 |
| DR‐MP | Delayed‐release mercaptopurine | − | +a, 72 |
| OS M1 | Soy‐derived extracts | +102 | − |
Tested for other indications.
