Table 2. Rates of spontaneous CanR and Lys+ mutations in ogg1, rad6 and rad18 mutants of S.cerevisiae.
Genotype | CanR mutation rate (10−7) | Lys+ mutation rate (10−8) |
---|---|---|
Wild-type | 3.6 ± 1.4 [1] | 3.8 ± 2.2 [1] |
Δ ogg1 | 18.0 ± 3.1 [5] | 33.3 ± 6.0 [9] |
Δ rad6 | 7.6 ± 1.4 [2] | 4.2 ± 1.2 [1] |
Δ rad18 | 12.9 ± 1.9 [4] | 9.7 ± 2.3 [3] |
Δ ogg1 Δ rad6 | 126.3 ± 11.5 [35] | 85.6 ± 13.6 [23] |
Δ ogg1 Δ rad18 | 109.4 ± 11.1 [30] | 126.6 ± 19.8 [33] |
Δ ogg1 Δ rad6 Δ rad18 | 105.6 ± 14.9 [29] | ND |
CanR and Lys+ mutation rates were determined using the method of the median (50). Numbers in brackets are the fold induction relative to the wild-type value. ND, not determined.