Table 3. Spectrum of CanR mutations.
| Genotype | Mutation | Occurrence | Mutation ratea (10−7) |
|---|---|---|---|
| Wild-type | GC to TA | 11/61 (18%) | 0.6 [1]b |
| GC to AT | 20/61 (33%) | 1.2 | |
| GC to CG | 8/61 (13%) | 0.5 | |
| AT to TA | 2/61 (3%) | 0.1 | |
| AT to CG | 7/61 (9%) | 0.3 | |
| AT to GC | 3/61 (5%) | 0.2 | |
| (−1) deletion | 5/61 (8%) | 0.3 | |
| Insertions | 2/61 (3%) | 0.1 | |
| Complexc | 3/61 (5%) | 0.3 | |
| Δ ogg1 | GC to TA | 45/56 (80%) | 14.4 [24] |
| GC to AT | 4/56 (7%) | 1.3 | |
| AT to TA | 2/56 (4%) | 0.7 | |
| AT to GC | 2/56 (4%) | 0.7 | |
| (+1) addition | 2/56 (4%) | 0.7 | |
| Insertion | 1/56 (2%) | 0.4 | |
| Δ rad6 | GC to TA | 7/31 (23%) | 1.7 [3] |
| GC to AT | 12/31 (39%) | 3.0 | |
| GC to CG | 1/31 (3%) | 0.2 | |
| AT to TA | 1/31 (3%) | 0.2 | |
| (−1) deletion | 4/31 (13%) | 1.0 | |
| (+1) addition | 4/31 (13%) | 1.0 | |
| Insertion | 1/31 (3%) | 0.2 | |
| Complex | 1/31 (3%) | 0.2 | |
| Δ rad18 | GC to TA | 16/30 (53%) | 6.8 [11] |
| GC to AT | 8/30 (27%) | 3.5 | |
| AT to TA | 3/30 (10%) | 1.3 | |
| AT to CG | 1/30 (3%) | 0.4 | |
| (−1) deletion | 1/30 (3%) | 0.4 | |
| (+1) addition | 1/30 (3%) | 0.4 | |
| Δ rad30 | GC to TA | 7/21 (33%) | 1.1 [2] |
| GC to AT | 3/21 (14%) | 0.4 | |
| AT to TA | 4/21 (19%) | 0.6 | |
| AT to CG | 1/21 (5%) | 0.2 | |
| AT to GC | 1/21 (5%) | 0.2 | |
| (−1) deletion | 4/21 (19%) | 0.6 | |
| Complex | 1/21 (5%) | 0.2 | |
| Δ ogg1 Δ rad6 | GC to TA | 27/30 (90%) | 113.7 [189] |
| GC to CG | 1/30 (3%) | 3.8 | |
| (−1) deletion | 2/30 (7%) | 8.8 | |
| Δ ogg1 Δ rad18 | GC to TA | 24/32 (75%) | 82.1 [137] |
| GC to AT | 5/32 (16%) | 17.5 | |
| AT to TA | 1/32 (3%) | 3.3 | |
| AT to CG | 1/32 (3%) | 3.3 | |
| AT to GC | 1/32 (3%) | 3.3 | |
| Δ ogg1 Δ rad30 | GC to TA | 29/30 (97%) | 88.7 [148] |
| AT to TA | 1/30 (3%) | 2.7 | |
| Δ ogg1 Δ rad18 | GC to TA | 28/30 (95%) | 169.4 [282] |
| Δ rad30 | AT to TA | 1/30 (3%) | 5.3 |
| (−1) deletion | 1/30 (3%) | 5.3 |
aCanR mutation rates are the product of the proportion of a specific class of mutation and the total mutation rate for each strain (Tables 2 and 4).
bNumber in brackets is the fold induction of GC to TA relative to the wild-type value.
cComplex mutations are the mutations that involve multiple molecular events such as base substitutions and frameshifts.