Table 4. Rates of spontaneous CanR and Lys+ mutations in ogg1, rad18, rev3 and rad30 mutants of S.cerevisiae.
Genotype | CanR mutation rate (10−7) | Lys+ mutation rate (10−8) |
---|---|---|
Wild-type | 3.6 ± 1.4 [1] | 3.8 ± 2.2 [1] |
Δ ogg1 | 18.0 ± 3.1 [5] | 33.3 ± 6.0 [9] |
Δ rev3 | 0.7 ± 0.3 [0.2] | 1.3 ± 0.4 [0.3] |
Δ rad30 | 3.2 ± 0.6 [1] | 6.4 ± 1.5 [2] |
Δ ogg1 Δ rad18 | 109.4 ± 11.1 [30] | 126.6 ± 19.8 [33] |
Δ ogg1 Δ rev3 | 12.8 ± 2.4 [4] | 28.1 ± 4.4 [7] |
Δ ogg1 Δ rad30 | 91.4 ± 6.7 [25] | 135.9 ± 19.5 [36] |
Δ ogg1 Δ rad18 Δ rev3 | 128.9 ± 16.7 [36] | ND |
Δ ogg1 Δ rad18 Δ rad30 | 178.3 ± 18.7 [50] | 190.7 ± 17.2 [50] |
The mutation rates are determined as described in Table 2. Numbers in brackets are the fold induction relative to the wild-type values. ND, not determined.