Table 4.
Predictors of disease progression: univariate analysis
| Unadjusted HR | 95% CI | p-value | |
|---|---|---|---|
| Age, years | |||
| Q1 [<55, n = 31] | Ref. | ||
| Q2 [55– 64, n = 40] | 0.990 | 0.463–2.160 | 0.979 |
| Q3 [65–72, n = 36] | 1.052 | 0.480–2.309 | 0.899 |
| Q4 [>72, n = 43] | 0.429 | 0.169–1.089 | 0.075 |
| Sex | |||
| Male | Ref. | ||
| Female | 1.351 | 0.731–2.496 | 0.337 |
| SGRQ | |||
| < 25 | Ref. | ||
| ≥ 25 | 1.562 | 0.875–2.789 | 0.132 |
| Radiologic feature | |||
| Nodular bronchiectatic disease | 1 | ||
| Fibrocavitary disease | 1.740 | 0.737–4.108 | 0.206 |
| Chest CT score | |||
| X | Ref. | ||
| X + 1 | 1.211 | 1.123–1.306 | <0.001 |
| Presence of cavity | |||
| Absent | Ref. | ||
| Present | 3.750 | 2.086–6.739 | <0.001 |
| Cholesterol, mg/dL | |||
| ≥ 200 | Ref. | ||
| < 200 | 1.263 | 0.673–2.371 | 0.467 |
| Albumin, g/dL | |||
| ≥ 3.5 | Ref. | ||
| < 3.5 | 8.942 | 3.097–25.818 | <0.001 |
| FVC, % | |||
| ≥ 80 | Ref. | ||
| < 80 | 1.974 | 1.049–3.715 | 0.035 |
| FEV1 | |||
| ≥ 80 | Ref. | ||
| < 80 | 1.102 | 0.546–2.226 | 0.786 |
| Height, cm | |||
| High [>165, n = 48] | Ref. | ||
| Middle [157–165, n = 55] | 1.126 | 0.547–2.319 | 0.748 |
| Low [<157, n = 47] | 1.243 | 0.604–2.562 | 0.555 |
| Weight, kg | |||
| High [>59, n = 49] | Ref. | ||
| Middle [50–59, n = 55] | 1.935 | 0.861–4.347 | 0.110 |
| Low [<50, n = 46] | 3.146 | 1.437–6.885 | 0.004 |
| BMI, kg/m2 | |||
| High [>22, n = 52] | Ref. | ||
| Middle [20–22, n = 44] | 1.619 | 0.669–3.752 | 0.261 |
| Low [<20, n = 54] | 3.211 | 1.538–6.705 | 0.002 |
| Waist, cm | |||
| High [>80, n = 50] | Ref. | ||
| Middle [72–80, n = 41] | 1.082 | 0.467–2.507 | 0.853 |
| Low [<72, n = 37] | 2.183 | 1.041–4.575 | 0.039 |
| Hip, cm | |||
| High [>95, n = 45] | Ref. | ||
| Middle [90–95, n = 48] | 2.062 | 0.890–4.780 | 0.092 |
| Low [<90, n = 35] | 2.485 | 1.041–5.929 | 0.040 |
| Skeletal muscle mass, kg | |||
| High [>23, n = 41] | Ref. | ||
| Middle [20–23, n = 43] | 1.068 | 0.434–2.629 | 0.886 |
| Low [<20, n = 44] | 2.382 | 1.083–5.242 | 0.031 |
| Body fat, kg | |||
| High [>16, n = 43] | Ref. | ||
| Middle [11.5–16, n = 42] | 2.565 | 1.045–6.300 | 0.040 |
| Low [<11.5, n = 43] | 3.068 | 1.270–7.409 | 0.013 |
| Body fat percentage, % | |||
| High [>29, n = 42] | Ref. | ||
| Middle [22.5–29, n = 40] | 2.545 | 1.037–6.246 | 0.041 |
| Low [<22.5, n = 46] | 2.609 | 1.081–6.296 | 0.033 |
| Abdominal fat ratio | |||
| High [>0.88, n = 51] | Ref. | ||
| Middle [0.84–0.88, n = 39] | 2.342 | 1.024–5.356 | 0.044 |
| Low [<0.84, n = 38] | 2.987 | 1.302–6.851 | 0.010 |
HR, hazard ratio; CI, confidence interval; SGRQ, St. George’s Respiratory Questionnaire; CT, computed tomography; BMI, body mass index; FVC, forced vital capacity; FEV 1, forced expiratory volume in 1 s; Ref, reference